DNA/RNA Core

Core Services

• Consultations and design services in the area of aptamers constructs and other complex oligonucleotides

• Synthesis of large amounts of unique oligoribonuleotides, modified/labeled on base or sugar

• Synthesis of large amounts of very pure, highly modified siRNA - for animal studies

• Synthesis of large amounts of very pure, highly modified RNA aptamers- for animal studies

• Synthesis of conjugates of biopolymers with specialized molecules and with other biopolymers, for example: siRNA-aptamer or DNA-peptide or saRNA-antibody.

• Core facilitates ordering and distribution of about 14,000 standard DNA and RNA oligos per year. Oligos are purchased from outside vendor. Sophisticated web application, Oligo Entry System, is used for ordering/report generation/billing/record keeping.
• Synthesis of oligoribonuleotides, modified/labeled on base or sugar
• Synthesis of siRNA, highly modified, large amounts, very pure - for animal studies
• Synthesis of conjugates of biopolymers with specialized molecules and with other biopolymers, for example: siRNA-aptamer or DNA-peptide.
• Synthesis of nucleoside based synthons for the synthesis of modified oligomers
• Core facilitates ordering and distribution of 10,000 standard DNA oligos per year. Oligos are purchased from outside vendor. Sophisticated web application is used for ordering/report generation/billing/record keeping.

Dr. Piotr M. Swiderski, received his Ph.D. degree from Poznan University, Poland.  

He co-authored 38 publications and 8 patents in the area of chemistry of nucleic acid.

PATENTS

1. 1. US Patent: 5766550 Piotr M. Swiderski, BE Kaplan, A single use disposable cartridge used for the storage and delivery of expensive amidites/reagents to the reaction cell of a DNA/RNA synthesizer (1994), issued in 1998.

   2. US Patent: 6379931 JJ Rossi, Piotr M. Swiderski, Chimeric and non-chimeric comprised of DNA, RNA, modified RNA and propanediols (1998), issued in 2002.

   3. US Patent: Q Liu, Piotr M. Swiderski, and SS Sommer, “Truncated amplification: a method for high-fidelity template-driven nucleic acid amplification” filled in 2002

   4. US Patent: M Kortylewski, Piotr M. Swiderski, JJ Rossi, R Jove, H Yu, “Methods and compositions for the treatment of cancer or other diseases,” Patent# 9688982, 10253318, 9200279, 9200280

   5. US Patent: JJ Rossi, Piotr M. Swiderski, J Zhou, “Cell-type specific aptamer - siRNA delivery system for HIV-1 therapy (1954-499)” filled in 2009

   6. US Patent: Kortylewski, Marcin; Swiderski, Piotr “STAT3 INHIBITORS AND USES THEREOF”, filled 2013

   7. US Patent: Swiderski, Piotr, “Multivalent Oligonucleotide Assembles”.

   Pub. Date Feb.2, 2017, Pub. No.: US 2017/0029816 A1

   8. US Patent: Kortylewski, Marcin; Swiderski, Piotr, Immunostimulatory CpG-STAT3 decoy oligodeoxynucleotides for therapy of metastatic cancers (TEC 13-042) (95058-889594)

   9. US Patent: Herrmann Andreas, Lin Lee, Shively John, Swiderski, Piotr, Yu Hua “Cell Penetrating Conjugates and Methods of Use Thereof” 95058-002701US-900656 filed in 2013

   10. US Patent: Swiderski, Piotr, Shively John, Rossi John “Bis-specific Conjugates” Filed in February 2017

   11. US Patent: Kortylewski, Marcin; Swiderski, Piotr; Steven Rosen, OLIGONUCLEOTIDE-BASED PROTEOLYSIS TARGETING CHIMERA AND THE USES THEREOF, filed on June 15, 2018, U.S. Serial No. 62/685,810

   12. US Patent: Kortylewski, Marcin; Swiderski, Piotr; OLIGONUCLEOTIDE INHIBITORS OF NUCLEAR FACTOR KAPPALIGHT-CHAIN-ENHANCER OF ACTIVATED B CELLS AND THE USESTHEREOF,”

   13. US Patent: Kortylewski, Swiderski, Marcucci, Zhang, Kuo, COMPOUNDS AND COMPOSITIONS INCLUDING PHOSPHOROTHIOATED OLIGONUCLEOTIDE, AND METHODS OF USE THEREOF Nov. 1, 2018

   14. US Patent: Marcin Tomasz Kortylewski, Guido Marcucci, Yu-Lin Su and Piotr Marek Swiderski, MICRORNA AS A THERAPEUTIC AGENT, Ref. No.: TEC 19-19-037, Filing Date: November 26, 2019

   15. US Patent: John E. Shively, Lin Li, Maciej Kujawski, Piotr Swiderski, COMPLEMENTARY RNA LINKED BISPECIFIC T-CELL ENGAGING ANTIBODIES, filed on October 15th, 2020, Application # 63/092,426

PUBLICATIONS

1. Kujawski, Maciej, Li, Lin; Li, Harry; Yazaki, Paul; Swiderski, Piotr; Shively, John, “T cell surface generation of dual bivalent, bispecific T-cell engaging, RNA duplex cross-linked antibodies (dbBiTERs) for re-directed tumor cell lysis” , Biotechnology Journal, DOI: 10.1002/biot.202100389

   2. Pinelopi Andrikakou; Vikash Reebye; Sorah Yoon; Daniel Vasconcelos; Jon Voutila; Andrew J.T. George; Piotr Swiderski; Robert Habib; Matthew Catley; David Blakey; Nagy A. Habib; John J. Rossi; Kai-Wen Huang, “Enhancing SIRT1 gene expression using small activating RNAs: A novel approach for reversing metabolic syndrome” Cell Metabolism

   3. Zhuoran Zhang, Xingli Zhao, Dongfang Wang, Dayson Moreira, Yu-Lin Su, Marice Alcantara, Piotr Swiderski, Jeffrey Wong, Susanta Hui, Stephen Forman, Larry Kwak, Marcin Kortylewski, “Targeted in vivo delivery of NF-kB decoy inhibitor auguments sensitivity of B-cell lymphoma to therapy” Molecular Therapy (Cell press). 4. Su YL, Wang X, Mann M, Adamus TP, Wang D, Moreira DF, Zhang Z, Ouyang C, He X, Zhang B, Swiderski PM, Forman SJ, Baltimore D, Li L, Marcucci G, Boldin M, Kortylewski M. Myeloid Cell-Targeted miR-146a Mimic Inhibits NF-kB-Driven Inflammation and Leukemia Progression in Vivo.Blood. 2019 Dec 5. pii: blood.2019002045. doi: 10.1182/blood.2019002045. [Epub ahead of print]

   5. Nuzzo, Silvia & Catuogno, Silvia & Capuozzo, Maria & Fiorelli, Alfonso & Swiderski, Piotr & Boccella, Serena & F, de & Esposito, Carla. (2019). “Axl-Targeted Delivery of the Oncosuppressor miR-137 in Non-small-Cell Lung Cancer”. Molecular Therapy - Nucleic Acids. 17. 10.1016/j.omtn.2019.06.002. Molecular Therapy - Nucleic Acids

   6. Yu-Lin Su, Xiuli Wang, Mati Mann, Tomasz Adamus, Dayson Moreira, Zhuoran Zhang, Ching Ouyang, Piotr Swiderski, David Baltimore, Stephen Forman, Ling Li, Marcin Kortylewski “Myeloid Cell-Selective miR-146a Mimic Inhibits NF-kB-Driven Inflammation and Tumorigenic Effects in Vivo” Blood

   7. Dayson Moreira, Tomasz Adamus, Xingli Zhao, Yu-Lin Su, Zhuoran Zhang, Seok White, Piotr Swiderski, Xin Lu, Ronald DePinho, Sumanta Pal, and Marcin Kortylewski Manuscript Number: CD-18-0429 , ”STAT3 inhibition combined with CpG immunostimulation activates antitumor immunity to eradicate genetically distinct castration-resistant prostate cancers” Published OnlineFirst October 18, 2018,doi: 10.1158/1078-0432.CCR-18-1277, Clinical Cancer Research,

   8. L.X. Nguyen , L. Li , D Zhao , B. Kumar , H. Wu , A. Lin , F. Pellicano , L. Hopcroft , Yu-Lin Su , M. Copland , T.L. Holyoake , C. Kuo , R. Bhatia , D. Snyder , H. Ali , A. Stein , C. Brewer , H. Wang , T. McDonald , Piotr Swiderski , E. Troadec , Ching-Cheng Chen , A. Dorrance , V. Pullarkat , Yate-Ching Yuan , D. Perrotti , N. Carlesso , Stephen J. Forman , M. Kortylewski , Ya-Huei Kuo , G. Marcucci, “Bone Marrow Niche Trafficking of miR-126 Controls Self-Renewal of Leukemia Stem Cells in Chronic Myelogenous Leukemia”, Nat Med 2018 May 5;24(4):450-462. Epub 2018 Mar 5.

   9. Yijie Wang, Jan Hoinka, Piotr Swiderski and Teresa Przytycka, “AptaBlocks: Accelerating the Design of RNA-based Drug Delivery Systems” RECOMB 2018, accepted to Cell Systems

   10. Xingli Zhao, Zhuoran Zhang, Dayson Moreira, Yu-Lin Su, Haejung Won, Tomasz Adamus, Zhenyuan Dong, Yong Liang, Hongwei Yin, Piotr Swiderski, Raju Pillai, Larry Kwak, Stephen Forman, and Marcin Kortylewski, "B-cell lymphoma immunotherapy using TLR9-targeted oligonucleotide STAT3 inhibitors" by Molecular Therapy. 2018 [Paper #MTJ-17-1760R2 11. Yu-lin Su , Zhuoran Zhang, Piotr Swiderski, Defu Zeng Guido Marcucci, Mark Boldin, Marcin Kortylewski,

   “Targeted Delivery of miR-146a Mimic Oligonucleotides as a Potential Therapeutic Approach to Modulate NF-kB Signaling in Myeloid Leukemia and Myeloproliferative Diseases”, Experimental Hematology 64 (2018) S41–S51

   12. Sorah Yoon, Kai-Wen Huang, Vikash Reebye, Duncan Spalding, Teresa M. Przytycka, Yijie Wang, Piotr Swiderski, Lin Li, Brian Armstrong, Isabella Reccia, Dimitris Zacharoulis, Konstantinos Dimas, Tomokazu Kusano, John Shively, Nagy Habib and John J. Rossi, “Aptamer drug conjugates (ApDCs) of active metabolites of nucleoside analogues and cytotoxic agents inhibit pancreatic tumorcell growth” Article (PDF Available) in Molecular Therapy - Nucleic Acids · December 2016 DOI: 10.1016/j.omtn.2016.11.008

   13. Sorah Yoon, Kai-Wen Huang,Vikash Reebye, Paul Mintz, Yu-Wen Tien, Hong-Shiee Lai, Pål Sætrom, Isabella Reccia, Piotr Swiderski, Brian Armstrong,Agnieszka Jozwiak,Duncan Spalding, Long Jiao, Nagy Habib and John

   J Rossi, “Targeted Delivery of C/EBPα -saRNA by Pancreatic Ductal Adenocarcinoma (PDAC)-specific RNA aptamers Inhibits Tumor Growth in Vivo” Accepted manuscript © 2016 The American Society of Gene & Cell Therapy. 14. Andrew R Chin, Miranda Y Fong, George Somlo, Jun Wu, Piotr Swiderski, Xiwei Wu, Emily Wang “Cross-kingdom inhibition of breast cancer growth by plant miR159” Article in Cell Research 26(2) · January 2016 DOI: 10.1038/cr.2016.13 15. Qifang Zhang, Dewan Md Sakib Hossain, Priyanka Duttagupta, Dayson Moreira, Xingli Zhao, Haejung Won, Ralf Buettner, Sergey Nechaev, Marcin Majka, Bin Zhang,Qi Cai, Piotr Swiderski, Ya-Huei Kuo, Stephen Forman, Guido Marcucci, and Marcin Kortylewski, “Serum-resistant CpG-STAT3 decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia” Blood. 2016 Mar 31; 127(13): 1687–1700. Prepublished online 2016 Jan 21. doi: 10.1182/blood-2015-08-665604, PMCID: PMC4817311 16. Hossain DM, Moreira D, Zhang Q, Nechaev S, Swiderski P, Kortylewski M. “TLR9-Targeted SiRNA Delivery In Vivo” Methods Mol Biol. 2016;1364:183-96. doi: 10.1007/978-1-4939-3112-5_15.

   17. John J. Rossi, Sorah Yoon, Nagy A. Habib, Paul J Mintz, Isabella Reccia, Kai-Wen Huang, Piotr Swiderski, Hong-Shiee Lai, Agnieszka Jozwiak, Brian Armstrong, Duncan Spalding, Long R Jiao, Vikash Reebye, Yu-Wen Tien, "C/EBPα -saRNA delivery by Pancreatic Ductal Adenocarcinoma (PDAC)-specific RNA aptamers inhibits tumor growth in vivo" PNAS, The manuscript has been assigned tracking number 2015-11598.

   18. Miranda Y. Fong, Weiying Zhou, Liang Liu, Aileen Y. Alontaga, Manasa Chandra, Jonathan Ashby, Amy Chow, Sean Timothy Francis O’Connor, Shasha Li, Andrew R. Chin, George Somlo, Melanie Palomares, Zhuo Li, Jacob R. Tremblay, Akihiro Tsuyada, Guoqiang Sun, Michael A. Reid, Xiwei Wu, Piotr Swiderski, Xiubao Ren, Yanhong Shi, Mei Kong, Wenwan Zhong,Yuan Chen and Shizhen Emily Wang, “Breast cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis” Nature Cell Biology 19. Esposito Cl, Cerchia L, Catuogno S, de Vita G, Dassie Jp, Santamaria G, Swiderski P, Condorelli G, Giangrande Ph, de Franciscis V, “Multifunctional aptamer-miRNA conjugates for targeted cancer therapy” Molecular Therapy 01/2014”

   20. Andreas Herrmann, Saul J. Priceman, Piotr Swiderski, Maciej Kujawski, Hong Xin, Gregory A. Cherryholmes, Wang Zhang, Chunyan Zhang, Christoph Lahtz, Claudia Kowolik, Steve J. Forman, Marcin Kortylewski and Hua Yu, “CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells”, J. Clin. Invest. 2014; 124(7):2977–2987, 21. Andreas Herrmann, Gregory Cherryholmes, Anne Schroeder, Jillian Phallen, Darya Alizadeh, Hong Xin, Tianyi Wang, Heehyoung Lee, Christoph Lahtz, Piotr Swiderski, Brian Armstrong, Claudia Kowolik, Gary L Gallia, Michael Lim, Christine E Brown, Behnam Badie, Stephen J Forman, Marcin Kortylewski, Richard Jove, Hua Yu “TLR9 is Critical for Glioma Stem Cell Maintenance and Targeting.” Cancer Research 07/2014; DOI: 10.1158/0008-5472.CAN-14-1151

   22. Hossain DM, Dos Santos C, Zhang Q, Kozlowska A, Liu H, Gao C, Moreira D, Swiderski P, Jozwiak A, Kline J, Forman S, Bhatia R, Kuo YH, Kortylewski M, “Leukemia cell-targeted STAT3 silencing and TLR9 triggering generate systemic antitumor immunity.”Blood, 02 January 2014, vol./is. 123/1(15-25), 0006-4971, 02 January 2014

   23. Reebye V, Saetrom P, Mintz PJ, Huang KW, Swiderski P, Peng L, Liu C, Liu X, Lindkaer-Jensen S, Zacharoulis D, Kostomitsopoulos N, Kasahara N, Nicholls JP, Jiao LR, Pai M, Spalding DR, Mizandari M, Chikovani T, Emara MM, Haoudi A, Tomalia DA, Rossi JJ, Habib NA, “Novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesis in vivo”., Hepatology (Baltimore, Md.), January 2014, vol./is. 59/1(216-27), 0270-9139, January 2014

   24. Nechaev S, Gao C, Moreira D, Swiderski P, Jozwiak A, Kowolik CM, Zhou J, Armstrong B, Raubitschek A, Rossi JJ, Kortylewski M, Intracellular processing of immunostimulatory CpG-siRNA: Toll-like receptor 9 facilitates siRNA dicing and endosomal escape. Journal of controlled release : official journal of the Controlled Release Society, 28 September 2013, vol./is. 170/3(307-15), 0168-3659, 28 September 2013 25. Chan Gao, Anna Kozlowska, Sergey Nechaev, Haiqing Li, Qifang Zhang, Dewan M.S. Hossain, Claudia M. Kowolik, Peiguo Chu, Piotr Swiderski, Don J. Diamond, Sumanta K. Pal, Andrew Raubitschek, and Marcin Kortylewski, “TLR9 signaling in the tumor microenvironment initiates cancer recurrence after radiation therapy”, Cancer Research, 2013 26. Charles Preston Neff, Jiehua Zhou, Leila Remling, Jes Kuruvilla, Jane Zhang, Haitang Li, David D Smith, Piotr Swiderski, John J Rossi, Ramesh, Akkina, “An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4(+) T cell decline in humanized mice”. Sci Transl Med. 2011 Jan 19;3(66):66ra6. doi: 10.1126/scitranslmed.3001581.

   27. C. Gao, A. Kozlowska, S. Nechaev, H. Li, D. Hossain, Q. Zhang, C. Kowolik, C. Peiguo, P. Swiderski, D. Diamond, A. Raubitschek, M. Kortylewski, “TLR9 triggers STAT3 signaling in myeloid cells to initiate tumor re-growth after radiation therapy” (our reference: 70663-RG-1) JCI 2013

   28. Zhang Q, Hossain DM, Nechaev S, Kozlowska A, Zhang W, Liu Y, Kowolik CM, Swiderski P, Rossi JJ, Forman S, Pal S, Bhatia R, Raubitschek A, Yu H, Kortylewski M, TLR9-mediated siRNA delivery for targeting of normal and malignant human hematopoietic cells in vivo.” Blood, 21 February 2013, vol./is. 121/8(1304-15), 0006-4971, 21 February 2013 29. Zhou J, Neff CP, Swiderski P, Li H, Smith DD, Aboellail T, Remling-Mulder L, Akkina R, Rossi JJ, “Functional in vivo delivery of multiplexed anti-HIV-1 siRNAs via a chemically synthesized aptamer with a sticky bridge.” Molecular therapy : the journal of the American Society of Gene Therapy, January 2013, vol./is. 21/1(192-200), 1525-0016, January 2013

   30. Jiehua Zhou, Katrin Tiemann, Pritsana Chomchan, Jessica Alluin, Piotr Swiderski, John Burnett, Stephen Forman, John Rossi, “Dual functional BAFF receptor aptamers inhibit ligand induced proliferation and deliver siRNAs to NHL cells”, Nucleic Acids Research 2012

   31. JJ. H. Zhou, C. P. Neff, X. X. Liu, J. Zhang, H. T. Li, D. D. Smith, P. Swiderski, T. Aboellail, Y. Y. Huang, Q. Du, Z. C. Liang, L. Peng, R. R. Akkina and J. J. Rossi, “Systemic administration of combinatorial dsiRNAs via nanoparticles efficiently suppresses HIV-1 infection in Mice”, Mol Ther. 2011 Dec;19(12):2228-38. doi: 10.1038/mt.2011.207. Epub 2011 Sep 27.

   32. J. H. Zhou, H. T. Li, J. Zhang, P. Swiderski and J. J. Rossi, “Development of cell-type specific anti-HIV gp120 aptamers for siRNA delivery”, Journal of Visualized Experiments-Infectious Diseases, doi: 10.3791/2954, Jun 23, 2011.

   33. C. P. Neff, J. H. Zhou, L. Remling, J. Zhang, H. T. Li, P. Swiderski, J. J. Rossi and R. Akkina, “An aptamer-siRNA chimera suppresses HIV-1 viral loads and protects from helper CD4+ T cells in humanized mice”. Science Translational Medicine, 2011, 3(66), 66ra6. 34. Ma Y, Kowolik CM, Swiderski PM, Kortylewski M, Yu H, Horne DA, Jove R, Caballero OL, Simpson AJ, Lee FT, Pillay V, Scott AM. Humanized Lewis-Y specific antibody based delivery of STAT3 siRNA.” ACS Chem Biol. 2011 Sep 16;6(9):962-70. Epub 2011 Jul 26.”

   35. Jiehua Zhou, Piotr M. Swiderski, Haitang Li, Jane Zhang, C. Preston Neff, Ramesh Akkina and John J. Rossi, “Selection,m characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells” , Nucleic Acids Research, 2009, Vol. 37, No. 9, 3094–3109

   36. Kortylewski M, Swiderski P, Herrmann A, Wang L, Kowolik C, Kujawski M, Lee H, Scuto A, Liu Y, Yang C, Deng J, Soifer HS, Raubitschek A, Forman S, Rossi JJ, Pardoll DM, Jove R, Yu H. “In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses.” Nat Biotechnol. 2009 Oct;27(10):925-32.

   37. Jing Song, Jianghai Wang, Agnieszka A. Jozwiak, Weidong Hu, Piotr M. Swiderski, Yuan Chen, “Stability of thioester intermediates in ubiquitin-like modifications (p NA)”, Protein Science, Accepted Article Online: Sep 25 2009 38. Hang Yuan, Linda Lanting, Zhong-Gao Xu, Shu-Lian Li, Piotr M. Swiderski, Sumanth Putta, Mahesh Jonnalagadda, Mitsuo Kato, Rama Natarajan ,”Effects of cholesterol-tagged small interfering RNAs targeting 12/15-lipoxygenase on parameters of diabetic nephropathy in a mouse model of type 1 diabetes” Am J Physiol. Renal Physiol. 2008 August; 295(2)

   39. Narkunarajaa Shanmugam, James L. Figarola, Yan Li, Piotr M. Swiderski, Samuel Rahbar, and Rama Natarajan “Proinflammatory Effects of Advanced Lipoxidation End Products in Monocytes”, Diabetes. 2008 April; 57(4): 879–888

   40. Jarrod Clark, Taras Shevchuk, Piotr M. Swiderski, Rajesh Dabur, Laura E. Crocitto, Yaroslav I. Buryanov, Steven S. Smith “Construction of Ordered Protein Arrays” (2005), Book Series: Methods in Molecular Biology, Book: Protein Nanotechnology, Volume 300, p325-348

   41. Jarrod Clark, Taras Shevchuk, Piotr M. Swiderski, Rajesh Dabur, Laura E. Crocitto, Yaroslav I. Butyanov and Steven S. Smith, (2003) “Mobility-shift analysis with microfluidics chips”, BioTechniques , Vol. 35, No. 3,

   42. Qiang Liu, Piotr M. Swiderski and Steve S. Sommer "Truncated Amplification for Template-Driven Nucleic Acid Amplification" Biotechniques, 33, No. 1, 129-138 (2002)

   43. David S. Snyder, Piotr M. Swiderski, Ross McMahon, Lijuan Yu, Ming-Jie Li, John J. Rossi, Stephen J. Forman and Yaping Wu, "Extremely efficient transfection of philadelphia chromosome-positive leukemia cells utilizing anti-bcr-abl cholesterol-conjugated DNAzymes" The American Society of Hematology 1999

   44. J.-H. Yoon, Piotr M. Swiderski, Bruce Kaplan, M. Takao, A. Yasui, Bing Shen, Gerd Pfeifer "Processing of UV damage by FEN-1 proteins in an alternative DNA excision repair pathway" Biochemistry, 38,4809-4817, 1999

   45. Pfeifer, G.P., Dammann, R., Tommasi, S., Tu, Y., Kaplan, B.E., and Swiderski, P. M. (1998) “Sequence-specific formation and repair of UV photoproducts in human cells”, Hönigsmann, H., Knobler, R.M., Trautinger, F. and Jori, G. (eds.), Landmarks in Photobiology, OEMF, Milano, Italy, pp. 236-239.

   46. Konopka K, Rossi JJ, Swiderski PM, Slepushkin VA, Duzgunes N "Delivery of an anti-HIV-1 ribozyme into HIV-infected cells via cationic liposomes." Biochim Biophys Acta 1998 Jun 24; 1372 (1):55-68

   47. Stella Tommasi, Piotr M. Swiderski, Yuging Tu, Bruce E. Kaplan, and Gerd P. Pfeifer, “Inhibition of Transcription Factor Binding by Ultraviolet-Induced Pyrimidine Dimers” Biochemistry, vol. 35, No. 49, 15693-15703 (1996)

   48. Olaf Heidenreich, Xiao Xu, Piotr M. Swiderski, John J. Rossi and Michael Nerenberg, "Correlation of activity with stability of chemically modified ribozymes in nuclei suspension" Antisense Research and Development, 6:111-118 (1996)

   49. Olaf Heidenreich, Shin-Heh Kang, David A. Brown, Xiao Xu, Piotr M. Swiderski, John J. Rossi, Fritz Eckstein and Michael Nerenberg, “Ribozyme-mediated RNA degradation of nuclei suspension” Nucleic Acids Research, Vol. 23, No. 12, 2223-2228 (1995)

   50. Piotr M. Swiderski, Eduard Bertrand, Bruce E. Kaplan, "Polystyrene Reverse-Phase Ion-Pair Chromatography of Chimeric Ribozymes" Analytical Biochemistry, 216, 83-86 (1994)

   51. DS Snyder, Y Wu, JL Wang, JJ Rossi, Piotr M. Swiderski, BE Kaplan and SJ Forman, “Ribozyme-mediated inhibition of bcr-abl gene expression in a Philadelphia chromosome-positive cell line” Blood 1993 82: 600-605

   52. Radhika Gade, Bruce E. Kaplan, Piotr M. Swiderski, and R. Bruce Wallace, “Incorporation of Nonbase Residues into Synthetic Oligonucleotides and Their Use in PCR” Genet. Anal. Tech. Appl. 10(2): 61-65, 1993

   53. Vuokko T. Tormanen, Piotr M. Swiderski, Gerd P. Pfeifer, Bruce E. Kaplan and Arthur D. Riggs, "Extension Product Capture Improves Genomic Sequencing And Footprinting By Ligation-Mediated PCR", Nucleic Acids Research, Vol. 20, No. 20, 5487-5488 (1992)

   54. Nerida Taylor, Bruce E. Kaplan, Piotr M. Swiderski, Haitang Li and John J. Rossi, "Chimeric DNA-RNA hammerhead ribozymes have enhanced in vitro catalytic efficiency and increased stability in vivo" Nucleic Acids Research, Vol. 20, No. 17, 4559-4565 (1992)

   55. Piotr M. Swiderski; W. Z. Antkowiak; R. W. Adamiak, “First, Solid Support-Aided Introduction of Isopentyladenosine, Hypermodified Nucleoside of tRNA, into Oligoribonucleotide Chain” Nucleosides, Nucleotides and Nucleic Acids, Vol. 10, Issue 1 - 3 January 1991 , 599 – 600

   56. Piotr M. Swiderski, P. Dembek, W. Z. Antkowiak, E. Biala, R. W. Adamiak, "Studies directed towards introduction of isopentenyladenosine and its 2-methylthio analog into oligoribonucleotides", Nucleic Acids Research, Symp. Series 18, 105 (1987)

   57. W. Z. Antkowiak, P. Dembek, J. Milecki, Piotr M. Swiderski, K. Weclawek, M. Wiewiorowski, "Efficient synthesis of oligoribonucleotides", Bull. Acad. Polon. Sci. Ser. Chem. v. XXVIII, nr.7-8, p.537 (1980)